Table 2. Associations of MCM6-rs3754686 with dairy and nutrient intake*.
| BPRHS | P | GOLDN | P | |||||
|---|---|---|---|---|---|---|---|---|
| Whole population | Whole population | |||||||
| CC (490) | CT (558) | TT (196) | CC (56) | CT (333) | TT (428) | |||
| Total dairy, | 372 ± 14 | 426 ± 13 | 407 ± 21 | 0.030 | 246 ± 28 | 358 ± 20 | 377 ± 16 | 4.2 × 10−3 |
| g/day | (0.031) | 0.0028 | 2.80E-03 | (2.8 × 10−3) | ||||
| Milk intake, | 315 ± 12 | 366 ± 12 | 342 ± 20 | 0.025 | 199 ± 26 | 316 ± 19 | 331 ± 15 | 2.2 × 10−3 |
| g/day | (0.037) | 0.0011 | 1.10E-03 | (1.1 × 10−3) | ||||
| Yogurt intake, | 32.8 ± 3.0 | 35.0 ± 2.8 | 36.3 ± 4.6 | 0.747 | 23.2 ± 5.8 | 18.7 ± 1.6 | 22.6 ± 1.9 | 0.494 |
| g/day | (0.663) | (0.515) | ||||||
| Cheese intake, | 23.8 ± 1.2 | 24.6 ± 1.1 | 28.4 ± 1.8 | 0.071 | 24.9 ± 2.8 | 22.7 ± 1.1 | 22.5 ± 1.0 | 0.268 |
| g/day | (0.142) | (0.165) | ||||||
| Calcium, mg/day | 1043 ± 27 | 1092 ± 25 | 1078 ± 42 | 0.337 | 828 ± 57 | 934 ± 29 | 942 ± 27 | 0.218 |
| Total energy intake, kcal/day | 2099 ± 40 | 2112 ± 38 | 2191 ± 63 | 0.177 | 2073 ± 106 | 2077 ± 46 | 2003 ± 49 | 0.210 |
| Total fat, %energy | 31.3 ± 0.2 | 31.1 ± 0.2 | 31.1 ± 0.4 | 0.980 | 37.1 ± 1.1 | 35.3 ± 0.4 | 35.5 ± 0.4 | 0.225 |
| Saturated fat, %energy | 9.3 ± 0.1 | 9.5 ± 0.1 | 9.6 ± 0.2 | 0.210 | 11.9 ± 0.4 | 11.8 ± 0.2 | 11.8 ± 0.1 | 0.866 |
| PREDIMED | WHI | |||||||
| Whole population | Whole population | |||||||
| CC (1642) | CT (3518) | TT (1967) | P | CC (5282) | CT (4368) | TT (1193) | P | |
| Total dairy, | 359 ± 5 | 386 ± 3 | 399 ± 5 | 1.3 × 10−6 | 127 ± 3 | 177 ± 3 | 211 ± 6 | 1.2 × 10−46 |
| g/day | (1.9 × 10−6) | 3.4E-66 | 3.4E-66 | (3.4 × 10−66) | ||||
| Milk intake, | 241 ± 4 | 261 ± 3 | 272 ± 4 | 9.8 × 10−6 | 94.5 ± 2.8 | 141.2 ± 3.1 | 169.3 ± 5.8 | 2.3 × 10−44 |
| g/day | (4.0 × 10−6) | 1.22E-65 | 1.2E-65 | (1.2 × 10−65) | ||||
| Yogurt intake, | 77.0 ± 2.1 | 82.6 ± 1.5 | 84.5 ± 2.1 | 0.131 | 27.5 ± 0.9 | 30.3 ± 1.0 | 36.1 ± 1.8 | 0.078 |
| g/day | (0.171) | 0.001859 | 1.9E-03 | (1.9 × 10−3) | ||||
| Cheese intake, | 29.7 ± 0.6 | 29.9 ± 0.5 | 30.1 ± 0.6 | 0.206 | 5.0 ± 0.1 | 5.7 ± 0.1 | 5.7 ± 0.3 | 3.8 × 10−3 |
| g/day | (0.266) | 2.86E-08 | 2.9E-08 | (2.9 × 10−8) | ||||
| Calcium, mg/day | 1019 ± 8 | 1046 ± 6 | 1065 ± 8 | 3.3 × 10−5 | N/A | |||
| Total energy intake, kcal/day | 2253 ± 14 | 2276 ± 10 | 2296 ± 14 | 0.009 | 1611 ± 11 | 1651 ± 12 | 1662 ± 23 | 0.057 |
| Total fat, %energy | 39.5 ± 0.2 | 39.2 ± 0.1 | 38.8 ± 0.2 | 0.298 | 34.7 ± 0.1 | 34.6 ± 0.1 | 33.9 ± 0.2 | 0.158 |
| Saturated fat, %energy | 10.0 ± 0.1 | 10.0 ± 0.0 | 9.9 ± 0.1 | 0.661 | 10.9 ± 0.0 | 11.1 ± 0.0 | 11.0 ± 0.1 | 0.010 |
*Values are means ± Standard Error of Mean. P-values adjusted for sex, age, field center or ancestry (BPRHS, WHI), family (GOLDN), BMI, smoking, drinking, physical activity, diabetes, medication and total energy intake. The rs3754686 SNP was determined in the PREDIMED Study and imputed in the BPRHS. The proxy SNP rs309180 was used in GOLDN and WHI studies.
**General Linear Regression models with multivariable adjustment for the indicated covariates were fitted for each population.
***Variables for dairy were used untransformed as well as square-root transformed to improve normality. The P-values without parentheses refer to the untransformed continuous variables, whereas values in parentheses refer to square-root transformed variables for dairy products.