Table 3. Associations of MCM6-rs3754686 proxy for milk intake with fasting glucose and lipids*.
| BPRHS | GOLDN | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CC (485) | CT (553) | TT (194) | P1 | P2 | CC (56) | CT (333) | TT (428) | P1 | P2 | |
| Glucose, mg/dL | 127 ± 3 | 120 ± 2 | 115 ± 4 | 0.036 | 0.032 | 103 ± 2 | 103 ± 1 | 101 ± 1 | 0.479 | 0.091 |
| Total cholesterol, mg/dL | 181 ± 2 | 181 ± 2 | 179 ± 3 | 0.914 | 0.968 | 197 ± 5 | 195 ± 2 | 191 ± 2 | 0.225 | 0.216 |
| LDL-C, mg/dL | 105 ± 2 | 105 ± 2 | 105 ± 3 | 0.981 | 0.939 | 127 ± 4 | 125 ± 2 | 123 ± 2 | 0.518 | 0.470 |
| HDL-C, mg/dL | 43.8 ± 0.6 | 44.3 ± 0.5 | 41.7 ± 0.9 | 0.038 | 0.041 | 46.9 ± 1.7 | 46.0 ± 0.7 | 45.9 ± 0.7 | 0.855 | 0.827 |
| Triglycerides, mg/dL | 168 ± 6 | 163 ± 5 | 169 ± 9 | 0.637 | 0.859 | 144 ± 11 | 142 ± 6 | 142 ± 5 | 0.894 | 0.827 |
| PREDIMED | WHI | |||||||||
| CC (1594) | CT (3399) | TT (1927) | P1 | P2 | CC (600) | CT (518) | TT (124) | P1 | P2 | |
| Glucose, mg/dL | 121 ± 40 | 123 ± 42 | 120 ± 41 | 0.421 | 0.793 | 106 ± 1 | 106 ± 2 | 103 ± 3 | 0.562 | 0.923 |
| Total cholesterol, mg/dL | 211 ± 38 | 211 ± 38 | 212 ± 42 | 0.763 | 0.722 | 222 ± 2 | 218 ± 2 | 220 ± 4 | 0.277 | 0.159 |
| LDL-C, mg/dL | 131 ± 34 | 130 ± 34 | 131 ± 38 | 0.922 | 0.551 | 138 ± 2 | 134 ± 2 | 135 ± 3 | 0.219 | 0.153 |
| HDL-C, mg/dL | 53.3 ± 13.5 | 53.9 ± 14.0 | 54.2 ± 14.7 | 0.045 | 0.044 | 57.0 ± 0.6 | 57.2 ± 0.6 | 58.0 ± 1.3 | 0.765 | 0.756 |
| Triglycerides, mg/dL | 139 ± 85 | 136 ± 75 | 138 ± 82 | 0.989 | 0.591 | 136 ± 3 | 135 ± 3 | 130 ± 6 | 0.828 | 0.429 |
*Values are means ± Standard Error of Mean. The rs3754686 SNP was determined in the PREDIMED Study and imputed in the BPRHS. The proxy SNP rs309180 was used in GOLDN and WHI studies.
**General Linear Regression models with multivariable adjustment for the indicated covariates were fitted for each population.
1P adjusted by sex, age, field center or race.
2P adjusted for sex, age, field center or ancestry (BPRHS, WHI), family (GOLDN), BMI, smoking, drinking, physical activity, diabetes, medication and total energy intake.
In PREDIMED, some variables (glucose, LDL-C, HDL-C and triglycerides) included missing data point. Biochemical data were available for fasting glucose (n = 6801 participants) total cholesterol (n = 6920 participants), HDL cholesterol (n = 6837 participants), LDL cholesterol (n = 6782 participants), and triglycerides (n = 6881 participants).