Table 3. Gene ontology analysis of molecular function of identified targets of let-7b and let-7c.
Molecular function | Frequency | P-value |
---|---|---|
Receptor activity (COL5A2, OSMR, IL6R, PRLR, COL4A6, COL4A1, COL3A1,COL27A1, ITGB6, COL1A2, COL1A1, GHR) | 12/1636 | 5.30e−5 |
Protein binding (FGF11, BCL2L1, NRAS, NGF, OSMR, IL6R, GNG5, PRLR, CCND2, CDKN1A, IGF1, GHR) | 12/2819 | 1.53e−2 |
Extracellular matrix structural constituent (COL5A2, COL4A6, COL4A1, COL3A1, COL27A1, COL1A2, COL1A1) | 7/76 | 1.22e−9 |
Transmembrane transporter activity (COL5A2, COL4A6, COL4A1, COL3A1, COL27A1, COL1A2, COL1A1) | 7/1010 | 4.02e−2 |
Receptor binding (FGF11, NGF, OSMR, IL6R, PRLR, IGF1, GHR) | 7/980 | 3.34e2 |
Structural molecular activity (COL5A2, COL4A6, COL4A1, COL3A1, COL27A1, COL1A2, COL1A1) | 7/1034 | 4.64e−2 |
Cytokine activity (NGF, OSMR, IL6R, PRLR, GHR) | 5/230 | 1.84e−3 |
Frequency is based on number of genes identified relative to total number of reference genes in humans for each molecular function.