Table 3. Gene ontology analysis of molecular function of identified targets of let-7b and let-7c.

Molecular function	Frequency	P-value
Receptor activity (COL5A2, OSMR, IL6R, PRLR, COL4A6, COL4A1, COL3A1,COL27A1, ITGB6, COL1A2, COL1A1, GHR)	12/1636	5.30e−5
Protein binding (FGF11, BCL2L1, NRAS, NGF, OSMR, IL6R, GNG5, PRLR, CCND2, CDKN1A, IGF1, GHR)	12/2819	1.53e−2
Extracellular matrix structural constituent (COL5A2, COL4A6, COL4A1, COL3A1, COL27A1, COL1A2, COL1A1)	7/76	1.22e−9
Transmembrane transporter activity (COL5A2, COL4A6, COL4A1, COL3A1, COL27A1, COL1A2, COL1A1)	7/1010	4.02e−2
Receptor binding (FGF11, NGF, OSMR, IL6R, PRLR, IGF1, GHR)	7/980	3.34e2
Structural molecular activity (COL5A2, COL4A6, COL4A1, COL3A1, COL27A1, COL1A2, COL1A1)	7/1034	4.64e−2
Cytokine activity (NGF, OSMR, IL6R, PRLR, GHR)	5/230	1.84e−3

Frequency is based on number of genes identified relative to total number of reference genes in humans for each molecular function.