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. 2016 Aug 9;6(8):e866. doi: 10.1038/tp.2016.137

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Results of tract-based spatial statistics (TBSS) analyses demonstrating significantly reduced fractional anisotropy (FA) values for the body of the corpus callosum (bCC) and genu of the corpus callosum (gCC) in medication-naive patients with major depressive disorder (MDD) (family-wise error corrected, P<0.01). Background images are the mean FA maps across all participants, with green voxels representing the mean FA skeleton images. Red and yellow voxels represent the white matter regions in which FA values were significantly lower in patients with MDD than in healthy controls. Enlarged images show the hand-drawn region-of-interest masks. Red areas represent the body of the corpus callosum and blue areas represent the genu of the corpus callosum.