Table 2. Top three most significant associations between BD-associated SNPs and EHR-derived phenotypes.
| SNP | Gene | chr | Position | Minor allele | MAF | OR for BD riska | P-value for BD riska | Phenotype | ORb | P-valueb |
|---|---|---|---|---|---|---|---|---|---|---|
| rs4765913 | CACNA1C | 12 | 2290157 | A | 0.21 | 1.15 | 1.4 × 10−6 | Cardiac dysrhythmias | 1.13 | 3.4 × 10−3 |
| rs7042161 | SVEP1 | 9 | 112237084 | T | 0.34 | 0.90 | 7.3 × 10−5 | Essential hypertension | 0.90 | 3.5 × 10−3 |
| rs10896135 | C11orf80 | 11 | 66307578 | C | 0.26 | 0.88 | 1.8 × 10−6 | Headache including migraine | 1.12 | 8.5 × 10−3 |
Abbreviations: BD, bipolar disorder; EHR, electronic health record; MAF, minor allele frequency; OR, odds ratio; SNP, single-nucleotide polymorphism.
a
OR and P-value for the minor allele from the Psychiatric Genomics Consortium BD GWAS.15
b
OR and P-value for the association between the SNP minor allele and the phenotype.