Figure 5.

GABA- and trkB-targeted intervention strategies have differential effects in mitigating context-elicited reward-seeking behavior. (a) Adolescent female mice respond for a sucrose+cocaine (7.5 μg ml⁻¹) reinforcer. A median split of total nose pokes highlights that approximately half of the mice develop low, stable response rates, whereas the other half develop an escalating response pattern. (b) The mice were then reintroduced to the conditioning chambers in adulthood. Mice with a history of stable responding generated robust response rates, relative to the final day of training. Baclofen further increased nose poking. (c) Responding on the ‘cocaine-taking lever' followed a different trend, however, and (d) activation of the dipper that previously delivered cocaine was significantly reduced. (e) By contrast, the trkB agonist 7,8-DHF reduced nose poking. Lever pressing and dipper delivery followed the same general trend, although interactions were nonsignificant (not shown). Means+s.e.m., *P<0.05.