Table 1.
Key characteristics of selected studies
| 1st author | Publication year | Method/Ligand | Reference region | Diagnosis | Severity ranting tools | Severity score | Controls (F) + age | Patients (F) + age | Treatment |
|---|---|---|---|---|---|---|---|---|---|
| Wayne C. Drevets | 1999 | PET [11C]WAY-100635 | Cerebellum | MDD, BPII | HAM-17 | 22 ± 6.4 | 8 (4) 35.3 ± 13.5 | 12 (7) 35.8 ± 9.7 | Drug free ≥2 week |
| Sargent P. Aa. | 2000 | PET [11C]WAY-100635 | Cerebellum | MDD, BPII | HAM-17 | 14.1 ± 194.9 | 18 (1) 36.4 ± 8.3 | 35 (3) 40 ± 34.5 | Drug free ≥12 |
| Z Bhagwagar | 2004 | PET [11C]WAY-100635 | Cerebellum | MDD | HAM-7 | 2.3 ± 1 | 18 (0) 43.2 ± 13 | 14 (0) 48 ± 14.9 | Drug free ≥25.7 week |
| Carolyn Cidis Meltzer | 2004 | PET [11C]WAY-100635 | Plasma | MDD | HAM-17 | 18.1 ± 2.7 | 17 (9) 70 ± 6.7 | 17 (13) 71.4 ± 5.9 | Drug free ≥2 week |
| Jussi Hirvonen△ | 2008 | PET [11C]WAY-100635 | Plasma | MDD | HAM-17 | 18.1 ± 2.9 | 15 (8) 32.6 ± 7.7 | 21 (8) 40.1 ± 9 | Drug free ≥17.1 week |
| Eydie L. Moses-kolko | 2008 | PET [11C]WAY-100635 | Cerebellum | Postpartum D. | HAM-17 | 21 ± 4.3 | 7 (7) 33 ± 3.9 | 9 (9) 26.9 ± 7.9 | 7 patients rdrug naïve |
| Ramin V. Parsey a△ | 2006b | PET [11C]WAY-100635 | Cerebellum | MDD | HAM-17 | 25.7 ± 7.08 | 43 (24) 38.2 ± 15 | 28 (7) 38.5 ± 29.3 | Drug free ≥2 week |
| Gregory M. Sullivan△ | 2009 | PET [11C]WAY-100635 | Cerebellar white matter | BPII | HAM-17 | 18 ± 4.9 | 47 (27) 38.1 ± 14.7 | 32 (19) 38.4 ± 9.7 | Drug free ≥2 week |
| Jeffrey Millera△ | 2012 | PET [11C]WAY-100635 | Cerebellum white matter | MDD | HAM-17 | 24.6 ± 5.3 | 51 (29) 37.3 ± 14.4 | 24 (17) 35 ± 13.3 | Drug free ≥3 |
| Allison C. Nugent | 2013a | PET [11C]WAY-100635 | Cerebellar white matte | BPII | MADRS | 23 ± 10 | 33 ± 9.4 | 26 (19) 33 ± 9.5 | Drug free ≥3 week |
MDD major depressive disorder, BP bipolar depression, PET positron emission tomography, HAMD Hamilton depression scale, MADRS Montgomery and Asberg depression rating scale
aData from subgroups were combined and averaged (severity score, age, BP values)
ΔBP values were acquired from figures by graphical software (GetData Graph Digitizer v2.2)