Table 2.

Top scoring networks from the IPA knowledge base that involve proteins differentially expressed in young compared with old chondrogenic, tenogenic and osteogenic constructs

Construct	Identification of associated network functions	Score
Chondrogenica	Cell death and survival, lipid metabolism, small molecule biochemistry	43
	Cellular movement, cell death and survival, cancer	33
	Connective tissue disorders, haematological disease, hereditary disorder	31
	Cellular assembly and organisation, cellular development, connective tissue development and function	28
	Cell signalling, nucleic acid metabolism, small molecule biochemistry	26
Tenogenica	Carbohydrate metabolism, haematological disease, immunological disease	59
	Developmental disorder, hereditary disorder, inflammatory disease	43
	Cell-to-cell signalling and interaction, embryonic development, tissue development	36
	Endocrine system development and function, energy production, small molecule biochemistry	36
	Cellular assembly and organisation, cellular function and maintenance, cellular compromise	31
Osteogenicb	Cellular assembly and organisation, tissue development, infectious disease	58
	Cellular compromise, developmental disorder, haematological disease	32
	Protein synthesis, developmental disorder, hereditary disorder	29
	Lipid metabolism, nucleic acid metabolism, small molecule biochemistry	8

^aSignificant DE proteins with p < 0.05, q < 0.05 and ±2-fold change

^bSignificant DE proteins with p < 0.05 and ±2-fold change

DE differentially expressed, IPA ingenuity pathway analysis