Table 4.
Summary of significant functional categories, canonical pathways and networks identified from DE proteins by IPA in constructs made from young or old MSCs for chondrogenic, tenogenic and osteogenic constructs
| Biological processes | Chondrogenica | Tenogenica | Osteogenicb |
|---|---|---|---|
| Antioxidant changes | ✓ | ✓ | ✓ |
| Cell death and survival | ✓ | ✓ | ✓ |
| Cytoskeleton changes | ✓ | ✓ | ✓ |
| Energy metabolism | x | ✓ | ✓ |
| Protein metabolism | x | ✓ | ✓ |
| Lipid metabolism | ✓ | x | ✓ |
| Musculoskeletal abnormalities increased | ✓ | ✓ | x |
| Cell movement | ✓ | ✓ | ✓ |
| Cell proliferation | ✓ | ✓ | ✓ |
| Integrin signalling | x | ✓ | ✓ |
aSignificant DE proteins with p < 0.05, q < 0.05 and ±2-fold change
bSignificant DE proteins with p < 0.05 and ±2-fold change
DE differentially expressed, IPA ingenuity pathway analysis, MSC mesenchymal stem cell