Table 1. Identified proteins with expression significantly altered in the liver of mice of group A/J control vs. 129 control (0 ppm F).
| Foldchange | |||||
|---|---|---|---|---|---|
| aAccess | Gene | Protein name description | PLGS score | A/J 0 ppm | 129P3/ J 0 ppm |
| Number | name | ||||
| Q921H8 | Acaa1a | 3-ketoacyl-CoA thiolase A, peroxisomal | 195.3 | 1.65 | -1.65 |
| Q8VCH0 | Acaa1b | 3-ketoacyl-CoA thiolase B, peroxisomal | 195.3 | 1.70 | -1.70 |
| Q8BWT1 | Acaa2 | 3-ketoacyl-CoA thiolase, mitochondrial | 189.2 | 1,42 | -1,42 |
| P63038 | Hspd1 | 60 kDa heat shock protein, mitochondrial | 153.6 | 1.55 | -1.55 |
| P20029 | Hspa5 | 78 kDa glucose-regulatedprotein | 254.4 | 1.43 | -1.43 |
| P68033 | Actc1 | Actin, alpha cardiacmuscle 1 | 630.1 | 1.28 | -1.28 |
| P68134 | Acta1 | Actin, alpha skeletalmuscle | 630.1 | 1.28 | -1.28 |
| P62737 | Acta2 | Actin, aorticsmoothmuscle | 60.2 | 1.35 | -1.35 |
| P60710 | Actb | Actin, cytoplasmic 1 | 62.4 | 1.25 | -1.25 |
| P63260 | Actg1 | Actin, cytoplasmic 2 | 62.4 | 1.26 | -1.26 |
| P63268 | Actg2 | Actin, gamma-enteric smooth muscle | 60.2 | 1.34 | -1.34 |
| P47738 | Aldh2 | Aldehydedehydrogenase, mitochondrial | 72.6 | 1.67 | -1.67 |
| P17182 | Eno1 | Alpha-enolase OS=Mus musculus | 129.4 | 1.46 | -1.46 |
| P16460 | Ass1 | Argininosuccinatesynthase | 58.6 | 1.28 | -1.28 |
| P05202 | Got2 | Aspartateaminotransferase, mitochondrial | 79.3 | 1.34 | -1.34 |
| Q03265 | Atp5a1 | ATP synthase subunit alpha, mitochondrial | 74.7 | 1.43 | -1.43 |
| P56480 | Atp5b | ATP synthasesubunit beta, mitochondrial | 138.6 | 1.35 | -1.35 |
| O35490 | Bhmt | Betaine--homocysteine S-methyltransferase 1 | 40.6 | 1.23 | -1.23 |
| Q8C196 | Cps1 | Carbamoyl-phosphate synthase [ammonia], mitochondrial | 269.2 | 1.39 | -1.39 |
| Q63880 | Ces3a | Carboxylesterase 3A | 336.9 | 1.46 | -1.46 |
| Q8VCU1 | Ces3b | Carboxylesterase 3B | 139.1 | 1.65 | -1.65 |
| P24270 | Cat | Catalase | 260.8 | 1.62 | -1.62 |
| Q8R0Y6 | Aldh1l1 | Cytosolic 10-formyltetrahydrofolate dehydrogenase | 53.1 | 1.55 | -1.55 |
| Q9DCW4 | Etfb | Electron transfer flavoprotein subunit beta | 174.4 | 1.48 | -1.48 |
| P10126 | Eef1a1 | Elongationfactor 1-alpha 1 | 245.5 | 1.39 | -1.39 |
| P70694 | Akr1c6 | Estradiol 17 beta-dehydrogenase 5 | 207.5 | 1.48 | -1.48 |
| Q91XD4 | Ftcd | Formimidoyltransferase-cyclodeaminase | 121.1 | 3.82 | -3.82 |
| Q91Y97 | Aldob | Fructose-bisphosphatealdolase B | 96.1 | 1.62 | -1.62 |
| P35505 | Fah | Fumarylacetoacetase | 136.0 | 1.46 | -1.46 |
| P26443 | Glud1 | Glutamatedehydrogenase 1, mitochondrial | 467.9 | 1.84 | -1.84 |
| P10649 | Gstm1 | Glutathione S-transferase Mu 1 | 129.1 | 1.26 | -1.26 |
| P15626 | Gstm2 | Glutathione S-transferase Mu 2 | 109.8 | 1.32 | -1.32 |
| P48774 | Gstm5 | Glutathione S-transferase Mu 5 | 109.8 | 1.32 | -1.32 |
| P19157 | Gstp1 | Glutathione S-transferase P 1 | 317.2 | -0.66 | 0.66 |
| P63017 | Hspa8 | Heat shock cognate 71 kDa protein | 275.2 | 1.36 | -1.36 |
| P01942 | Hba | Hemoglobinsubunit alpha | 1252.1 | -0.85 | 0.85 |
| P02104 | Hbb-y | Hemoglobinsubunit epsilon-Y2 | 854.2 | -0.48 | 0.48 |
| Q8CGP6 | Hist1h2ah | Histone H2A type 1-H | 193.0 | 1.22 | -1.22 |
| Q64522 | Hist2h2ab | Histone H2A type 2-B | 241.3 | 1.51 | -1.51 |
| P62806 | Hist1h4a | Histone H4 | 88.1 | 1.54 | -1.54 |
| P54869 | Hmgcs2 | Hydroxymethylglutaryl-CoAsynthase, mitochondrial | 292.1 | 1.22 | -1.22 |
| P11588 | Mup1 | Major urinaryprotein 1 | 815.0 | -0.53 | 0.53 |
| B5X0G2 | Mup17 | Major urinaryprotein 17 | 824.6 | -0.54 | 0.54 |
| P11589 | Mup2 | Major urinaryprotein 2 | 815.0 | -0.54 | 0.54 |
| P11591 | Mup5 | Major urinaryprotein 5 | 389.7 | -0.57 | 0.57 |
| P02762 | Mup6 | Major urinaryprotein 6 | 815.0 | -0.53 | 0.53 |
| P04938 | Mup8 | Major urinary proteins 11 and 8 (Fragment) | 815.0 | -0.54 | 0.54 |
| P08249 | Mdh2 | Malatedehydrogenase, mitochondrial | 247.9 | 1.45 | -1.45 |
| Q64374 | Rgn | Regucalcin | 107.2 | 1.36 | -1.36 |
| P24549 | Aldh1a1 | Retinaldehydrogenase 1 | 208.9 | 1.49 | -1.49 |
| P07724 | Alb | Serumalbumin | 108.5 | 1.34 | -1.34 |
| P00329 | Adh1 | Alcoholdehydrogenase 1 | 163.3 | + | - |
| Q61234 | Snta1 | Alpha-1-syntrophin | 77.6 | + | - |
| Q8VCT3 | Rnpep | Aminopeptidase B | 73.8 | + | - |
| Q9D3D9 | Atp5d | ATP synthasesubunit delta, mitochondrial | 183.6 | + | - |
| Q62210 | Birc2 | Baculoviral IAP repeat-containing protein 2 | 65.9 | + | - |
| Bad | Q61337 | Bcl2 antagonist of cell death | 116.2 | - | + |
| P21550 | Eno3 | Beta-enolase | 161.0 | + | - |
| P34914 | Ephx2 | Bifunctionalepoxidehydrolase 2 | 441.9 | + | - |
| Q8R1G2 | Cmbl | Carboxymethylenebutenolidasehomolog | 73.2 | + | - |
| Q61686 | Cbx5 | Chromoboxproteinhomolog 5 | 96.9 | + | - |
| Q3V079 | Ccdc176 | Coiled-coil domain-containing protein 176 | 66.5 | + | - |
| P50172 | Hsd11b1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 100.4 | + | - |
| Cth | Q8VCN5 | Cystathioninegamma-lyase | 100.5 | - | + |
| P48771 | Cox7a2 | Cytochrome c oxidase subunit 7A2, mitochondrial | 185.6 | + | - |
| P10518 | Alad | Delta-aminolevulinicaciddehydratase | 316.8 | + | - |
| Q9DBT9 | Dmgdh | Dimethylglycinedehydrogenase, mitochondrial | 89.4 | + | - |
| Q99LC5 | Etfa | Electron transfer flavoprotein subunit alpha, mitochondrial | 77.6 | + | - |
| Q9ER73 | Elp4 | Elongatorcomplexprotein 4 | 103.4 | + | - |
| P63242 | Eif5a | Eukaryotic translation initiation factor 5A-1 | 104.8 | + | - |
| Q9QXD6 | Fbp1 | Fructose-1,6-bisphosphatase 1 | 154.4 | + | - |
| P17183 | Eno2 | Gamma-enolase | 159.3 | + | - |
| Q3UHD2 | Gfod1 | Glucose-fructose oxidoreductase domain-containing protein 1 | 83.6 | + | - |
| P11352 | Gpx1 | Glutathioneperoxidase 1 | 419.0 | + | - |
| P24472 | Gsta4 | Glutathione S-transferase A4 | 127.0 | + | - |
| Q9QYE6 | Golga5 | Golginsubfamily A member 5 | 103.4 | + | - |
| P07901 | Hsp90aa1 | Heat shock protein HSP 90-alpha | 67.4 | + | - |
| P11499 | Hsp90ab1 | Heat shock protein HSP 90-beta | 107.9 | + | - |
| P68433 | Hist1h3a | Histone H3.1 | 163.6 | + | - |
| P84228 | Hist1h3b | Histone H3.2 | 163.6 | + | - |
| P84244 | H3f3a | Histone H3.3 | 163.6 | + | - |
| P02301 | H3f3c | Histone H3.3C | 163.6 | + | - |
| Hgd | O09173 | Homogentisate 1,2-dioxygenase | 95.6 | - | + |
| Hadh | Q61425 | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 183.9 | - | + |
| Q5U5V2 | Hykk | Hydroxylysinekinase | 78.0 | + | - |
| Q8BLR9 | Hif1an | Hypoxia-induciblefactor 1-alpha inhibitor | 96.3 | + | - |
| O88844 | Idh1 | Isocitratedehydrogenase [NADP] cytoplasmic | 69.5 | + | - |
| Q9CPU0 | Glo1 | Lactoylglutathionelyase | 203.5 | + | - |
| P06151 | Ldha | L-lactatedehydrogenase A chain | 153.0 | + | - |
| Acsl1 | P41216 | Long-chain-fatty-acid--CoA ligase 1 | 48.0 | - | + |
| Q9DB40 | Med27 | Mediator of RNA polymerase II transcription subunit 27 | 68.9 | + | - |
| Q8BPT6 | Immp2l | Mitochondrial inner membrane protease subunit 2 | 65.7 | + | - |
| Myef2 | Q8C854 | Myelinexpressionfactor 2 | 44.9 | - | + |
| Q9DC69 | Ndufa9 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplexsubunit 9, mitochondrial | 79.2 | + | - |
| Ncoa5 | Q91W39 | Nuclear receptor coactivator 5 | 67.7 | - | + |
| P11725 | Otc | Ornithinecarbamoyltransferase, mitochondrial | 217.0 | + | - |
| O08807 | Prdx4 | Peroxiredoxin-4 | 391.3 | + | - |
| Prdx5 | P99029 | Peroxiredoxin-5, mitochondrial | 174.7 | - | + |
| O08709 | Prdx6 | Peroxiredoxin-6 | 321.1 | + | - |
| P09411 | Pgk1 | Phosphoglyceratekinase 1 | 106.8 | + | - |
| Pgap2 | Q3TQR0 | Post-GPI attachment to proteins factor 2 | 60.0 | - | + |
| Prdm12 | A2AJ77 | PR domainzincfingerprotein 12 | 43.7 | - | + |
| Q80U40 | Rimbp2 | RIMS-bindingprotein 2 | 74.3 | + | - |
| B2RY56 | Rbm25 | RNA-bindingprotein 25 | 80.8 | + | - |
| Q91X83 | Mat1a | S-adenosylmethionine synthase isoform type-1 | 177.4 | + | - |
| Q99J08 | Sec14l2 | SEC14-like protein 2 | 106.4 | + | - |
| P47758 | Srprb | Signal recognition particle receptor subunit beta | 68.7 | + | - |
| Hspa9 | P38647 | Stress-70 protein, mitochondrial | 119.8 | - | + |
| Q8K2B3 | Sdha | Succinatedehydrogenase [ubiquinone] flavoproteinsubunit, mitochondrial | 74.3 | + | - |
| Q62264 | Thrsp | Thyroid hormone-inducible hepatic protein | 180.0 | + | - |
| P97360 | Etv6 | Transcriptionfactor ETV6 | 64.7 | + | - |
| Tmem42 | Q9CR22 | Transmembraneprotein 42 | 110.6 | - | + |
| Tpi1 | P17751 | Triosephosphateisomerase | 149.7 | - | + |
| Q9D6F9 | Tubb4a | Tubulin beta-4A chain | 101.3 | + | - |
| P68372 | Tubb4b | Tubulin beta-4B chain | 109.0 | + | - |
| Ube2w | Q8VDW4 | Ubiquitin-conjugatingenzyme E2 W | 102.0 | - | + |
| Q5QNV8 | Heatr9 | Uncharacterizedprotein C17orf66 homolog | 91.1 | + | - |
| N/A | Q8C4X7 | UPF0258 protein KIAA1024-like homolog | 38.4 | - | + |
| P25688 | Uox | Uricase | 92.7 | + | - |
The identified proteins are organized according to alphabetical order. Relative differential is indicated by + sign, when the protein is up-regulated and by - sign, when the protein is down-regulated in the respective comparison. aIdentification is based on protein ID from UniProt protein database (http://www.uniprot.org/)