Table 4.

Sequential models of binary logistic regression analysis evaluating independent predictors of NASH within NAFLD patients (n=31; sum of SS and NASH patients).

Variable	B	Exp(B)	p-value	95% CI for Exp(B)
Model 1α
Activin A (ng/ml)	3.62	37.3	0.21	0.13 – 10962
Model 1b
Follistatin (ng/ml)	2.12	8.3	0.063	0.89 – 78.1
Model 2
Activin A (ng/ml)	4.39	80.3	0.21	0.08 – 77055
Follistatin (ng/ml)	2.36	10.6	0.053	0.97 – 114
Model 3
Activin A (ng/ml)	3.85	46.8	0.16	0.22 – 9883
Follistatin (ng/ml)	2.77	16.0	0.046	1.06 – 242
Gender (0: men; 1: women)	1.25	3.48	0.235	0.44 – 27.3
Model 4
Activin A (ng/ml)	3.73	41.6	0.16	0.22 – 7911
Follistatin (ng/ml)	2.75	15.6	0.044	1.07 – 227
Gender (0: men; 1: women)	1.09	2.98	0.32	0.35 – 25.3
Age (years)	0.03	1.0	0.65	0.92 – 1.14
Model 5a
Activin A (ng/ml)	−0.17	0.8	0.97	0 – 16165
Follistatin (ng/ml)	2.83	17.0	0.038	1.17 – 247
Gender (0: men; 1: women)	1.38	4.0	0.27	0.34 – 46.2
Age (years)	0.04	1.0	0.53	0.93 – 1.2
BMI (kg/m2)	0.05	1.0	0.65	0.86 – 1.3
Model 5b
Activin A (ng/ml)	−0.16	0.9	0.97	0 – 7088
Follistatin (ng/ml)	2.73	15.3	0.050	1.00 – 233
Gender (0: men; 1: women)	1.39	4.0	0.26	0.36 – 44.6
Age (years)	0.04	1.0	0.50	0.93 – 1.16
Waist circumference (cm)	0.02	1.0	0.56	0.95 – 1.11
Model 5c
Activin A (ng/ml)	5.32	204.6	0.19	0.07 – 612686
Follistatin (ng/ml)	3.10	22.2	0.054	0.95 – 516
Gender (0: men; 1: women)	1.50	4.49	0.28	0.30 – 66.6
Age (years)	0.03	1.0	0.64	0.92 – 1.14
Leptin (ng/ml)	−0.02	1.0	0.60	0.91 – 1.06

SS was rated as 0 and NASH as 1 within dependent variable.

Abbreviations:: BMI, body mass index; HOMA-IR, homeostasis model of assessment insulin resistance, NASH, nonalcoholic steatohepatitis; SS, simple steatosis.