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. 2016 Sep;55(3):395–406. doi: 10.1165/rcmb.2016-0005OC

Figure 7.

Figure 7.

AFC in the absence or presence of terbutaline and Western analysis of β2-adrenergic receptor (β2AR) expression in Na pump β1 knockout mice. (A) AFC measurements in the absence of terbutaline demonstrated lower AFC in Atp1b1Aqp5-cre versus control mice. In contrast, terbutaline-stimulated AFC in Atp1b1Aqp5-cre mice reached 22.5 ± 2.6% per hour (n = 4), which was not significantly different from Atp1b1F/F control mice (27.3 ± 4.7% per hour, n = 4). (B) AFC in the absence of terbutaline was significantly lower in Atp1b1Sftpc-cre versus control mice, whereas terbutaline-stimulated AFC in Atp1b1Sftpc-cre mice was 30.9 ± 1.0% per hour (n = 4), which was not significantly different from Atp1b1F/F control mice (36.4 ± 2.9% per hour, n = 4). (C and D) Western analysis of β2AR protein in whole lung in (C) Atp1b1Aqp5-cre and (D) Atp1b1Sftpc-cre mice shows increased expression in both knockout lines compared with Atp1b1F/F control mice. *P < 0.05; **P < 0.01.