Table 2. Hazard ratios of Osteoporosis between gastric disease with late HP Eradication and control subjects as well as gastric disease with early HP Eradication and control subjects stratified by demographics and comorbidity.
| Control (N = 21788) | Early HP Eradication (N = 2721) | IRR * | Adjusted HR† | Late HP Eradication (N = 2726) | IRR* | Adjusted HR† | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case | Rate# | Case | Rate# | (95% CI) | (95% CI) | Case | Rate# | (95% CI) | (95% CI) | |
| All | 564 | 4.69 | 98 | 6.09 | 1.30 (1.16, 1.45)*** | 1.52 (1.23, 1.89)*** | 136 | 9.84 | 2.10 (1.91, 2.31)*** | 1.69 (1.39, 2.05)*** |
| Gender | ||||||||||
| Female | 369 | 7.89 | 60 | 10.0 | 1.27 (1.07, 1.50)** | 1.43 (1.09, 1.88)** | 79 | 14.5 | 1.83 (1.57, 2.13)*** | 1.63 (1.27, 2.10)*** |
| Men | 195 | 2.65 | 38 | 3.77 | 1.42 (1.23, 1.64)*** | 1.76 (1.24, 2.49)** | 57 | 6.82 | 2.57 (2.28, 2.90)*** | 1.76 (1.29, 2.40)*** |
| Age | ||||||||||
| ≤49 | 82 | 1.31 | 20 | 2.08 | 1.59 (1.36, 1.86)*** | 1.62 (0.99, 2.65) | 18 | 2.91 | 2.23 (1.89, 2.62)*** | 1.80 (1.06, 3.06)* |
| ≥50 | 482 | 8.38 | 78 | 12.1 | 1.44 (1.24, 1.67)*** | 1.41 (1.11, 1.79)** | 118 | 15.4 | 1.84 (1.63, 2.09)*** | 1.54 (1.25, 1.90)*** |
| Comorbidity‡ | ||||||||||
| No | 366 | 3.68 | 59 | 4.67 | 1.27 (1.12, 1.44)*** | 1.49 (1.13, 1.96)** | 50 | 6.08 | 1.65 (1.44, 1.89)*** | 1.60 (1.19, 2.16)** |
| Yes | 198 | 9.52 | 39 | 11.4 | 1.19 (0.96, 1.49) | 1.57 (1.11, 2.21)* | 86 | 15.4 | 1.61 (1.37, 1.90)*** | 1.70 (1.32, 2.19)*** |
Rate#, incidence rate, per 1000 person-years; IRR*, incidence rate ratio; Adjusted HR†, multiple analysis including age, sex, and co-morbidities of CAD, alcohol-related illness, stroke, COPD, asthma, rheumatoid arthritis, medication of steroid used; Comorbidity‡: Only to have one of comorbidities (including CAD, alcohol-related illness, stroke, COPD, asthma, rheumatoid arthritis) classified as the comorbidity group
*p<0.05
**p<0.01
***p<0.001