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. 2016 Sep 14;11(9):e0162645. doi: 10.1371/journal.pone.0162645

Table 3. Hazard ratios of Osteoporosis between all gastric disease patients with early HP Eradication and with late HP Eradication stratified by demographic characteristics and comorbidity.

Early HP Eradication Late HP Eradication
IRR* Adjusted HR IRR* Adjusted HR
(95% CI) (95% CI) (95% CI) (95% CI)
All 1 (Reference) 1 (Reference) 1.61 (1.38, 1.89)*** 1.11 (0.85, 1.46)
Gender
Female 1 (Reference) 1 (Reference) 1.44 (1.13, 1.84)** 1.11 (0.79, 1.57)
Men 1 (Reference) 1 (Reference) 1.81 (1.48, 2.22)*** 1.02 (0.66, 1.58)
Age
≤49 1 (Reference) 1 (Reference) 1.40 (1.09, 1.79)** 1.15 (0.59, 2.22)
≥50 1 (Reference) 1 (Reference) 1.28 (1.04, 1.57)* 1.10 (0.82, 1.48)
Comorbidity
No 1 (Reference) 1 (Reference) 1.30 (1.07, 1.59)** 1.05 (0.72, 1.53)
Yes 1 (Reference) 1 (Reference) 1.35 (1.04, 1.77)* 1.09 (0.75, 1.60)

IRR*, incidence rate ratio; Adjusted HR, multiple analysis including age, sex, and co-morbidities of CAD, alcohol-related illness, stroke, COPD, asthma, rheumatoid arthritis; Comorbidity: Only to have one of comorbidities (including CAD, alcohol-related illness, stroke, COPD, asthma, rheumatoid arthritis) classified as the comorbidity group

*p<0.05

**p<0.01

***p<0.001