Table 3. Multivariate analysis for risk factors of bacteremia during the early transplant period of tandem HDCT/auto-SCT.
Potential risk factors | Gram-positive bacteremia | Gram-negative bacteremia | ||||
---|---|---|---|---|---|---|
OR | 95% CI | p-value | OR | 95% CI | p-value | |
Second HDCT/auto-SCT (compared to the first) | 0.72 | 0.21~2.49 | 0.604 | 0.67 | 0.32~1.40 | 0.286 |
Inclusion of TBI and/or thiotepa in HDCT regimen | 6.28 | 1.34~29.50 | 0.020 | 0.60 | 0.29~1.26 | 0.178 |
Infused CD34+ cells <2 × 106/kg | 3.35 | 1.02~10.98 | 0.046 | 1.40 | 0.63~3.12 | 0.416 |
Age at transplantation >100 months | 0.93 | 0.26~3.29 | 0.911 | 2.56 | 1.25~5.24 | 0.010 |
OR, odds ratio; CI, confidence interval; HDCT/auto-SCT, high-dose chemotherapy and autologous transplantation; TBI, total body irradiation.