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. 2016 Sep 14;11(9):e0162916. doi: 10.1371/journal.pone.0162916

Fig 1. Changes of CD133 expression and histones H3 and H4 acetylation in UKF-NB-3 and SH-SY5Y after cultivation with 1mM VPA, valpromide, other HDAC inhibitors and cytostatics.

Fig 1

(A) VPA increased CD133 expression in UKF-NB-3 and SH-SY5Y. (B) VPM failed to influence CD133 expression or histone acetylation after cultivation with non-toxic doses for 72 hrs. (C) CD133 expression correlated with the changes of histones H3 and H4 acetylation when cultured with different HDAC inhibitors. (D) CD133 expression correlated with the changes of histones H3 and H4 acetylation when cultured with high doses of CDDP or VCR and in combination with VPA for 24 hrs.