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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: J Allergy Clin Immunol. 2016 Sep;138(3):639–652. doi: 10.1016/j.jaci.2016.06.003

Fig 3. Regulation and suppression of allergic innate immune responses by TReg cells.

Fig 3

TReg cells control innate immune cell subsets involved in promoting allergy. TReg cells block mast cell activation and the release of pre-formed anaphylactic mediators through OX40-OX40L mediated interactions. TReg cells also impede the IL-33-driven ILC2 expansion in the intestinal mucosa and their subsequent IL-4 production. Adapted version from the graphical abstract of ref. 107.