Table 4. Baseline laboratory parameters.
| AmBisome + SSG | AmBisome + miltefosine | Miltefosine | ||
|---|---|---|---|---|
| N = 51 | N = 49 | N = 51 | ||
| Haemoglobin | mean (SD) | 7.4 (1.8) | 7 (1.3) | 7 (1.3) |
| (g/dL) | median (range) | 7.3 (5–12.9) | 6.9 (5–9.7) | 6.8 (5–10.3) |
| White-cell Count | mean (SD) | 2.7 (1.3) | 2.3 (1.2) | 2.6 (1) |
| (x103/μL) | median (range) | 2.6 (1–7.4) | 2.1 (1–5.5) | 2.4 (1–5.2) |
| Platelets | mean (SD) | 130 (90) | 101 (54) | 114 (65) |
| (x103/μL) | median (range) | 104 (47–471) | 88 (39–288) | 100 (35–313) |
| AST | mean (SD) | 48 (25.9) | 56.2 (31.7) | 49 (29.9) |
| (U/L) | median (range) | 44 (8–112) | 50 (3–115) | 43.5 (3–117) |
| ALT | mean (SD) | 34.3 (20.5) | 40.5 (27.1) | 32.9 (20.7) |
| (U/L) | median (range) | 25 (2–87) | 32 (4–102) | 27.5 (7–102) |
| Creatinine | mean (SD) | 73.7 (26) | 71.2 (24.7) | 78 (21.2) |
| (μmol/L) | median (range) | 75 (35.4–129) | 70.7 (26.5–114.9) | 79 (35.4–132) |
| Blood urea nitrogen | mean (SD) | 5.7 (3.2) | 5.8 (2.8) | 5.7 (3.1) |
| (mmol/L) | median (range) | 5.3 (1.7–12.5) | 6.1 (1.3–11.4) | 5 (1.3–17.1) |
| Alkaline phosphatase | mean (SD) | 222 (196) | 211 (157) | 197 (117) |
| (U/L) | median (range) | 184 (10–1272) | 169 (62–817) | 176 (35–464) |
| Bilirubin | mean (SD) | 8.3 (4.8) | 8.3 (4.6) | 8.7 (5.2) |
| (total, mmol/L) | median (range) | 6.8 (2–27.4) | 6.8 (1.7–22) | 6.8 (3–27.4) |
| Sodium | mean (SD) | 137 (7) | 135 (8) | 134 (7) |
| (mmol/L) | median (range) | 137 (120–159) | 136 (110–149) | 133 (120–149) |
| Potassium | mean (SD) | 3.8 (0.4) | 3.8 (0.4) | 3.9 (0.4) |
| (mmol/L) | median (range) | 3.8 (2.9–4.6) | 3.8 (2.9–4.6) | 3.9 (2.8–4.9) |
| Magnesium | mean (SD) | 0.9 (0.3) | 0.9 (0.2) | 0.9 (0.2) |
| (mmol/L) | median (range) | 1 (0.2–1.9) | 1 (0.2–1.6) | 1 (0.4–1.5) |
ALT: Alanine transaminase; AST: aspartate aminotransferase