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. 2016 Sep 14;11(9):e0161965. doi: 10.1371/journal.pone.0161965

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© 2016 Andritschke et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — (A) SPIRE1 and SPIRE2 expression as measured by RT-qPCR upon RNAi treatment. Columns represent mean and error bars show standard deviation. (B) Small scale validation screen using S. Tm^SipA and the modified gentamicin protection assay to confirm phenotype of SPIRE2. (C) Modified gentamicin protection assay using Spire1^gt/gt and Spire2^-/- iMEFs infected with S. Tm^SipA normalized to the wild type iMEF control cell line. A shows data from 2 independent experiments with 2 replicates each in HeLa Kyoto cells. B and C show data from 3 independent experiments with 3 replicates each. Asteriscs indicate significant differences. *: p<0.05.