Table 3. ARQ 087 activity in FGFR dysregulated cell lines.

Cancer	Cell Line	FGFR Status [ref.]	ARQ 087 GI50 μM
Colon	NCI-H716	FGFR2 amp / FGFR2-COL14A1 fusion [44]/[45]	0.10
Gastric	SNU-16	FGFR2 amp / PDHX-FGFR2 fusion [11]/[45]	0.10
Blood	KG-1	FGFROP2-FGFR1 fusion [46]	0.13
Gastric	KATO-III	Amplified FGFR2 [11]	0.20
Ovarian	SKOV3	Over expression FGFR4 [47]	0.28
Bladder	J82	FGFR3 5652E [48]	0.30
Ovarian	A2780	Over expression FGFR 4 [47]	0.33
Leukemia	K-562	Over expression FGFR3 / 4 [49]	0.40
Breast	MFM-223	Amplified FGFR2 [42]	0.50
Bladder	RT112	FGFR3-TACC3 fusion [19]	0.65
Endometrial	MFE-280	FGFR2 S252W [50]	0.9
Endometrial	MFE-296	FGFR2 N549K [50]	1.0
Bladder	RT4	FGFR3-TACC3 fusion [19]	1.2
Bladder	SW-780	FGFR3-BAIAP2L1 fusion [19]	1.4
Endometrial	AN3CA	FGFR2 N549K [50]	1.7