Table 1. Microscopy and gross anastomosis assessment (min/med/max)(days) in short bowel-rats and in short bowel-rats that received diclofenac (12 mg/kg intraperitoneally).
| Microscopy and gross anastomosis assessment | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameters assessed | Massive small bowel resection | Massive small bowel resection | |||||||||
| Diclofenac | |||||||||||
| saline | BPC157 μg | saline | BPC157 μg | BPC 157 ng | L-NAME | L-arg | L-NAME+L-arg | L-NAME+BPC 157μg | L-arg +BPC 157 μg | L-NAME+L-arg+BPC 157μg | |
| Edemascored 0–3 | 3/3/3 | 1/1/1* | 3/3/3 | 1/1/1* | 1/1/1* | 3/3/3 | 2/2/2* | 3/3/3 | 1/1/2* | 1/1/1* | 1/1/2* |
| Granulationscored 0–3 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 |
| Necrosis scored 0–3 | 2/2/2 | 1/1/1* | 3/3/3 | 2/2/2 | 2/2/2 | 3/3/3* | 2/3/3 | 3/3/3* | 2/2/2 | 2/2/2 | 2/2/2 |
| Number of inflammatory cells | 150/169/185 | 120/135/154* | 170/189/ 205 | 135/148/164* | 145/159/172* | 190/219/ 225* | 160/180/ 195 | 180/189/ 195* | 143/153/169* | 133/140/163* | 130/158/170* |
| Intestinal obstruction scored 0–3 | 1/1/1 | 0/0/0* | 1/1/1 | 0/0/0* | 0/0/0* | 1/1/2 | 1/1/1 | 1/1/1 | 0/0/0* | 0/0/0* | 0/0/0* |
| Adhesions scored 0–7 | 1/1/1 | 0/0/0* | 1/1/1 | 0/0/0* | 0/0/0* | 1/1/2 | 1/1/1 | 1/1/1 | 0/0/0* | 0/0/0* | 0/0/0* |
BPC 157 (10 μg/kg, 10 ng/kg), L-NAME (5 mg/kg), L-arginine (100 mg/kg) were applied alone and/or combined while controls received an equivolume of saline (5 ml/kg) intraperitoneally.
*P<0.05, at least, vs. control