Table 2. Brain lesions (scored 0–4, or 0–3, Min/Med/Max) in short bowel-rats and in short bowel-rats that received diclofenac (12 mg/kg intraperitoneally).
| Brain lesions | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Brain edemascored 0–3 | Massive small bowel resection | Massive small bowel resection | |||||||||
| Diclofenac | |||||||||||
| Balonized or red neuronsscored 0–4 | sali-ne | BPC157 μg | sali-ne | BPC157 μg | BPC 157 ng | L-NAME | L-arg | L-NAME+L-arg | L-NAME+BPC 157 μg | L-arg+BPC 157 μg | L-NAME+L-arg+BPC 157μg |
| Edema | 3/3/3 | 0/0/0* | 3/3/3 | 1/1/1* | 1/1/1* | 3/3/3 | 2/2/2* | 3/3/3 | 1/1/2* | 1/1/1* | 1/1/2* |
| Cerebral | 3/3/3 | 1/1/1* | 3/3/3 | 1/1/1* | 1/1/1* | 4/4/4 | 2/2/2* | 3/3/3 | 1/1/2* | 1/1/1* | 1/1/2* |
| Cerebellar nn | 2/2/2 | 1/1/1* | 4/4/4 | 1/1/1* | 1/1/1* | 4/4/4 | 2/3/3* | 4/4/4 | 2/2/2* | 2/2/2* | 2/2/2* |
| Purkinje cells | 1/1/1 | 0/0/0* | 2/2/2 | 1/1/1* | 1/1/1* | 3/3/3 | 2/2/2* | 2/2/2 | 1/1/1* | 1/1/1* | 1/1/1* |
| Hippocam-pus | 3/3/3 | 1/1/1* | 3/3/3 | 1/1/1* | 1/1/1* | 4/4/4 | 2/2/2* | 3/3/3 | 1/1/1* | 1/1/1* | 1/1/1* |
BPC 157 (10 μg/kg, 10 ng/kg), L-NAME (5 mg/kg), L-arginine (100 mg/kg) were applied alone and/or combined while controls received an equivolume of saline (5 ml/kg) intraperitoneally.
*P<0.05, at least, vs. control.