Figure 1.

The reconstructed pathway of methanol and methylamine utilization in Methyloversaltilis universalis FAM5 based on genomic, transcriptomic and mutagenesis data. Genes mutated in this study are shown in red. Pathways upregulated (6–11 fold) by growth on methylamine are shown in green; Pathways slightly downregulated (1.5–3 fold) by growth on methylamine are shown in orange; Grey lines show pathways whose expression do not change; and Blue lines indicate steps that are not expressed on tested C1-compounds, methanol or methylamine.