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Ad5-CMV-mTNFα/Ad5-CMV-mIL2 dual virus combination together with adoptive T-cell transfer. Adenoviruses coding for mTNFα and mIL2 were combined in a 1 to 1 ratio (0.5 × 109 VP of each virus) to treat B16-OVA tumors together with adoptive transfer of 1.5 × 106 CD8-enriched OT-I T-cells. Virus treatments continued every 7 days. Error bars, mean + SEM, n = 8. *P < 0.05, ***P < 0.001.
