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. 2016 Jun 28;24(8):1395–1404. doi: 10.1038/mt.2016.95

Figure 3.

Figure 3

Analysis of NIS mRNA expression in HuH7 tumors. NIS protein expression in HuH7 xenografts was analyzed by immunohistochemistry 48 hours after cMET-targeted polyplex-mediated gene transfer on frozen tumor sections from mice that received cMBP2-PEG-Stp/NIS (a,b), from mice that received control polyplexes (Ala-PEG-Stp/NIS (c), cMBP2-PEG-Stp/Antisense-NIS (d)) and from untreated mice (e). Scale bar = 100 µm. Tumoral NIS mRNA expression levels after application of cMBP2-PEG-Stp/NIS with and without sodium perchlorate pretreatment, Ala-PEG-Stp/NIS and cMBP2-PEG-Stp/Antisense-NIS were examined by quantitative polymerase chain reaction (f).