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Chemical structures and synthesis of hydrophobically modified siRNAs (hsiRNAs). (a) Fully chemically stabilized hsiRNA with either docosahexaenoic acid (DHA) or cholesterol (Chol) bioconjugates at the 3′-end of the sense strand. Molecular models of hsiRNA represented to scale using PyMOL. The PyMOL Molecular Graphics System, Version 1.8 Schrödinger, LLC. (b) Solid-phase synthesis of DHA-conjugated hsiRNA. Htt, Huntingtin.
