Figure 6.

Affinity between polymer and oligonucleotide. (a) Electrophoretic mobility of Polymer/2′-OMePS complexes at three weight ratio of Rw = 1, 2, and 5 (from left to right for each polymer, 1 µg oligonucleotide in a total of 24 µl medium was used. The first lane on the left is loaded with 1 µg oligonucleotide only). (b) PEA 01 with 2′-OMePS/PMO at different weight ratios (5 µg PEA 01 used in this experiment in total of 24 µl). (c) Negative staining TEM images of PEA 01/oligonucleotide condensates: PEI 01/PMO (10 µg, 5 µg) and PEI 01/2′-OMePS (10 µg, 2 µg) in 500 µl 0.9% Saline (scale bar = 100 nm).