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. 2016 Aug 30;5(8):e358. doi: 10.1038/mtna.2016.70

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Molecular changes accompanying NCL-APT and LNA-NCL-APT treatment on Y79 xenograft. (a) Graph showing the levels of Y79 xenograft tumor tissue miRNA (miR-330, miR-206, miR-196b and miR-18a) normalized to vehicle control using U6 as internal control. (b) Graph showing the levels of serum miRNA post treatment with nucleolin aptamer. Normal serum (mice without tumor) was used for normalizing the expression levels.(c) Western blotting for Bcl2, Survivin, FOXM1 proteins from xenograft tissues of the control group and treated group tissues. The levels of apoptotic markers (d) in tumor tissue and serum cytokines (e) using protein array. The integrated pixel densities of the spots were quantified using ImageJ software and plotted as graph. The error bar represents the SD and the * indicates significance of P<0.05 and ** indicates significance of P < 0.001, for panel A, treated groups were normalized to vehicle control group, for panel B - normal serum was compared to vehicle control, then the vehicle control group was used to analyze the significance in treated groups. (f) IHC for PCNA expression. The images are taken under 40X objective. The intensity of expression is indicated in the bottom left.