Fig. 2.
Chronology of the protocol for 18 h experiments. Animals were sensitized on day 0. Recipient rats were depleted of their AMs on day 17. BAL was performed in donor rat on day 19 to retrieve AMs. These cells were cultured for 18 h, before being transferred into AM-depleted rats. Antigen challenge was performed the next day (day 21) and AHR was measured or BAL performed 24 h later. BAL, bronchoalveolar lavage; AM, alveolar macrophage; AHR, airway hyperresponsiveness; OVA, ovalbumin.