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. Author manuscript; available in PMC: 2018 Feb 28.
Published in final edited form as: Cancer Lett. 2016 Mar 14;387:121–126. doi: 10.1016/j.canlet.2016.03.015

Figure 1. Design Schematics.

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a. Enrichment or Targeted Design. R = randomization M+=marker positive, M−=marker negative TA=Targeted Agent

b. Marker Stratified or Marker-by-Treatment Interaction Design. R = randomization M+=marker positive, M−=marker negative TA=Targeted Agent

c. Marker Strategy Design. R = randomization.

d. Modified Marker Strategy Design. R = randomization, TA = Targeted Agent.

e. Umbrella Design. R = randomization. TA = Targeted Agent. SoC = Standard of Care. RCT = randomized controlled trial.

f. Adaptive Design. R = randomization. TA = Targeted Agent. SoC = Standard of Care.

g. Basket Trial Design. TA = Targeted Agent.