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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Addict Biol. 2016 Mar 14;22(4):977–990. doi: 10.1111/adb.12386

Figure 4. Drug priming-induced reinstatement at different withdrawal periods (Exp. 3).

Figure 4

Left panel: between-subjects assessment. Right panel: within-subjects assessment. (A) Extinction responding: Total number of active lever presses in rats tested in the extinction context (context A, with cue) after 1 day, 1 week, or 1 month of withdrawal. (B) Extinction time course: Number of active lever presses over six 1-h extinction sessions in rats tested in context A (with cue) after 1 day, 1 week, or 1 month of withdrawal. (C) Priming-induced reinstatement: Total number of active lever presses for priming induced reinstatement (0, 0.25, and 0.5 mg/kg, i.p.) after 1 day, 1 week, or 1 month of withdrawal * Differences between 1 day and 1 month, # differences between 1 day and 1 week, p<0.05.