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. Author manuscript; available in PMC: 2016 Sep 30.
Published in final edited form as: Oncogene. 2016 Mar 14;35(39):5093–5105. doi: 10.1038/onc.2016.52

Table 1. Histopathological analysis following long-term DHX9 suppression in DHX9/rtTA mice.

Histopathological analysis was performed on representative tissues extracted from FLuc.1309/rtTADHX9.837/rtTA, and DHX9.1271/rtTA mice treated with 1 mg/ml DOX for 6 months. Multifocal, random microgranulomas (Grade 1) were present in the liver of all mice analyzed and are likely a consequence of non-specific bacterial or viral infection. One DHX9.837/rtTA (+DOX) liver sample displayed moderate hepatic lipidosis which was not observed in the DHX9.1271/rtTA liver sample.

FLuc.1309/
rtTA		 FLuc.1309/
rtTA		 DHX9.837/
rtTA		 DHX9.1271/
rtTA
DOX: − + + +
Skin N N N N
Small Intestine N N N N
Large Intestine N N N N
Liver A A A A
Microgranuloma,
multifocal,
random		 1 1 1 1
Hepatic lipidosis,
microvacuolar,
centrolubular,
diffuse		 3
Thymus N N N N
Spleen N N N N
Heart N N N N

Key: N = no significant lesion, A = lesion observed, 0 = no tissue; Grade 1 = modest, rare, Grade 2 = mild, infrequent, Grade 3 = moderate, frequent, Grade 4 = severe, diffuse.