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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Mitochondrion. 2016 Jul 14;30:105–116. doi: 10.1016/j.mito.2016.07.003

Figure 3.

Figure 3

Multi-level organization of mitochondrial molecular composition, structures, functions, and signaling roles within the cell. These nested facets of mitochondrial functions are depicted hierarchically in a Maslow-type pyramidal fashion with the most basic determinants at the bottom and more complex and emergent elements above. These facets of mitochondria (first level) are regarded as determinants of higher-level physiological functions (second level), which in turn influence systems-level functions (third level) that contribute to clinical outcomes and mortality. Figure adapted from (Juster et al., 2011).