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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2016 Aug 15;308:11–19. doi: 10.1016/j.taap.2016.08.012

Figure 8. Ethanol-induced endoplasmic reticulum (ER) stress in the pancreas.

Figure 8

Six hours after the last ethanol exposure, mice were euthanized and the pancreatic tissues were processed for the immunoblotting analysis of ER stress markers (p-eiF2α, XBP-1, CHOP, ATF6, p-PERK, GRP78 and GRP94) (A and B). The antibody for XBP-1 recognizes both spliced XBP-1 (sXBP-1) and un-spliced XBP-1 (uXBP-1). The relative expression of these ER stress markers were quantified and normalized to α-tubulin (C-I). Each data point was the mean ± SEM of three animals. * denotes statistical difference (p<0.05) and ** denotes significant difference (p<0.01).