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G-protein activation by Ric-8. A GDP-bound Gα subunit disassociates from the membrane and can interact with a GPR-domain containing protein. This complex can then interact with Ric-8, which facilitates the exchange of GTP for GDP. Once activated, Gα can go on to interact with downstream effectors. The signal is terminated when Gα-GTP interacts with a RGS protein, which promotes the hydrolysis of GTP to GDP.
