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. Author manuscript; available in PMC: 2017 Sep 25.
Published in final edited form as: J Mol Biol. 2016 Aug 8;428(19):3850–3868. doi: 10.1016/j.jmb.2016.08.002

Table 1. Gα subunit interacting proteins.

Gα subunit Well-defined G-protein effectors Other G-protein interacting proteins
Gαs, Gαolf Adenylate cyclase (+) Tubulin, Calnuc, Src tyrosine kinase, axin
Gαo, Gαi1–3, Gαt1,2, Gαg, Gαz Adenylate cyclase (-), cGMP phosphodiesterase (+) Rap1Gapll, Calnuc, Src tyrosine kinase, nucleobindin 2 (NUCB2), Tubulin, Pins, Pcp1, LGN, GRIN1, Eya2, Pcp2
Gαq, Gα11, Gα14, Gα15/16 Phospholipase C-β (+), p63RhoGEF GRK2, actin, tubulin, PI3K, TPR1, Btk tyrosine kinase, Phospholipase C-ε, TRPM8
Gα12, Gα13 p115RhoGEF, LARG and PDZ-RhoGEF Gap1, rasGap, Btk tyrosine kinase, Radixin, Hax-1, Cadherins, α-SNAP, p120caterin, Integrin αlllbβ3

(+) indicates stimulation. (-) represents inhibition.