Table 3.

Information on seizures in children with SLC13A5 mutations in this study.

Subject	Seizure onset	Seizure types	Current seizure frequency	Most effective medications	Ketogenic diet effects	Seizures worse with fasting
1	First week of life	Complex partial GTC Myoclonic	>100/day	Acetazolamide Carbamazepine Diazepam Felbamate Phenobarbital Phenytoin*	Seizures worse Dystonia worse	Y
2	First week of life	Atonic hemiplegia	0–5/month	Acetazolamide Phenobarbital	NT	N
3	First week of life	Complex partial Focal motor Myoclonic	100 s/day with 3–5 wks seizure-free periods	Diazepam Lamotrigine Phenobarbital Phenytoin	NT	Y
4	First week of life	Complex partial Focal motor Myoclonic Tonic	>50/day	Clobazam Clonazepam Lorazepam Midazolam	Seizures worse	Y
5	First week of life	Focal motor Myoclonic	1/month	Clobazam Clonazepam Lamotrigine	NT	N
6	First week of life	Complex partial GTC	1/month	Acetazolamide Phenytoin	NT	N
7	<1 year old	Absence Complex partial Focal motor GTC Myoclonic	Rare (no specific frequency reported)	Acetazolamide Clonazepam Lamotrigine Valproic acid	No effect reported	N
8	First week of life	Focal motor GTC Myoclonic	1/month to 3/year	Acetazolamide Clonazepam Lamotrigine Valproic acid	NT	N
9	First week of life	Absence Atonic Complex partial Focal motor GTC Infantile spasms Myoclonic Tonic	1/wk	Lamotrigine Oxcarbazepine Topiramate	Seizures worse	N

GTC, generalized tonic clonic; NT, has not been treated with ketogenic diet; Y, yes; N, no. *Phenytoin improved seizures, but caused myoclonus.