Table 1.
Effect of various doses of hydroalcoholic extract of Indian propolis extract (HEIP) on MMC-induced micronucleus in bone marrow cells of Swiss albino mice at 24 h after injection (N = 12)
| Groups | MN incidence (%) | P/N ratio |
|---|---|---|
| Control | 0.31 ± 0.07 | 0.94 ± 0.01 |
| HEIP 100 | 0.33 ± 0.33 | 0.97 ± 0.06 |
| HEIP 200 | 0.05 ± 0.05 | 1.05 ± 0.02 |
| HEIP 300 | 0.03 ± 0.03 | 1.02 ± 0.02 |
| HEIP 400 | 0.18 ± 0.06 | 1.07 ± 0.04 |
| HEIP 600 | 0.21 ± 0.07 | 1.04 ± 0.04 |
| HEIP 800 | 0.02 ± 0.02 | 1.06 ± 0.02 |
| MMC (8 mg/kg) | 12.51 ± 0.48a | 0.69 ± 0.04d |
| HEIP 100 + MMC | 8.13 ± 0.45c | 0.71 ± 0.02 |
| HEIP 200 + MMC | 7.74 ± 0.44c | 0.69 ± 0.01 |
| HEIP 300 + MMC | 7.49 ± 0.81c | 0.81 ± 0.03e |
| HEIP 400 + MMC | 6.93 ± 0.66c | 0.82 ± 0.02e |
| HEIP 600 + MMC | 9.91 ± 0.93b | 0.70 ± 0.04 |
| HEIP 800 + MMC | 11.57 ± 0.54 | 0.64 ± 0.01 |
a P < 0.001 compared to control
b P < 0.05, c P < 0.001 compared to MMC alone for MN
d P < 0.001 compared to control
e P < 0.05 compared to MMC alone for P/N ratio