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. 2016 Aug 23;68(5):1925–1936. doi: 10.1007/s10616-016-0003-1

Table 4.

Relative gene expression of selected genes in IPEC-J2 cells after incubation for 4 h in different MCFAs

Immunological response Morphological response
IL-6 IL-8 IL-12 TLR-4 OCLN ZO-1 CLDN-4
C8 (mM)
 0.5 1.090 0.818 1.508 0.877 0.811* 0.981 1.122
 1.0 0.921 0.733 1.494 0.972 0.728* 0.762* 1.072
 2.0 0.906 0.770 1.454 1.124 0.762* 0.801* 1.303*
 5.0 1.383* 0.625* 1.036 1.332* 0.878 0.891 2.291*
 8.0 1.908* 0.449* 0.998 1.449* 0.820 0.893 3.177*
 10.0 2.132* 0.328* 0.934 1.589* 0.746* 0.838 2.573*
C10 (mM)
 0.5 0.833* 0.666* 1.115 0.989 0.766* 0.746* 0.984
 1.0 0.831* 0.690* 1.155 1.111 0.779* 0.821a 1.211a
 2.0 0.866a 0.676* 1.166 1.287* 0.619* 0.787a 1.442*
 5.0 1.390* 0.652* 0.751a 1.185a 0.512* 0.966 1.392*
C12 (mM)
 0.5 0.723* 0.700* 1.261 0.864 0.921 0.933 1.265*
 1.0 0.822* 0.843 1.551 0.952 0.808* 0.933 1.182
 2.0 0.973 0.638* 1.246 0.902 0.738* 0.863 1.467*

* Significantly different to control (p ≤ 0.05)

aTrend for significant difference to control (p ≤ 0.1)