Table 3.
Association of Ego and Alter Risk Factors for T2D with Incident Ego T2D, Stratified by Ego T2D Genetic Risk Score
| Low genetic risk score* | High genetic risk score* | |||
|---|---|---|---|---|
| Characteristic | OR (95 % CI) | p value | OR (95 % CI) | p value |
| Ego age | 1.07 (1.04, 1.10) | < 0.0001 | 1.05 (1.03, 1.07) | < 0.0001 |
| Ego sex | 1.65 (1.01, 2.68) | 0.04 | 1.30 (0.93, 1.82) | 0.13 |
| Ego parental history | 2.79 (1.69, 4.58) | < 0.0001 | 2.62 (1.83, 3.76) | < 0.0001 |
| Ego obesity (t−1) | 4.34 (2.71, 6.95) | < 0.0001 | 4.41 (3.08, 6.32) | < 0.0001 |
| Alter obesity (t−1) | 0.96 (0.71, 1.30) | 0.79 | 1.34 (1.10, 1.64) | 0.004 |
| Alter diabetes (t−1) | 1.22 (0.76, 1.96) | 0.40 | 1.35 (1.02, 1.77) | 0.03 |
Model: Outcome is incident ego T2D at a given exam (time t); primary exposures are alter obesity at the prior exam (time t−1) and alter T2D at the prior exam (time t−1), adjusting for ego age, sex, parental T2D history, ego obesity at the prior exam (time t−1), and ego network size
Abbreviations: OR Odds Ratio; 95 % CI 95 % Confidence Interval
p values are from multivariable generalized estimating equations applied to a binary outcome (T2D)
*Low T2D genetic risk score was defined as < 66.9 (the median GRS), and high genetic risk score was defined as ≥ 66.9