Fig. 1.

There is a decrease in the trabecular number in the subchondral bone of A2BRKO mice. Trabecular number was determined by μCT in 6, 12, and 19-week-old WT and A2BRKO mice. Plotted in the two graphs are the mean trabecular number in femur and tibia of WT and A2BRKO mice collected at different ages. Representative 2D images of subchondral femur of 6-week-old A2BRKO and WT mice. Data are expressed as mean ± SEM of four animals for each group and significance of differences was determined by two-way ANOVA and Bonferroni post hoc test; *p < 0.05; **p < 0.01; ***p < 0.001