Fig. 5.

Increased differentiation and functionality of A2BRKO osteoclasts—more bone marrow-derived osteoclast precursors from A2BRKO mice differentiate into osteoclasts in response to M-CSF/RANKL than from precursors isolated from WT mice (a; n = 4 experiments performed in duplicate) with a decrease in gene expression for ADGRE (F4/80, a macrophage marker) and an increase for Cathepsin K gene expression (b; n = 3 experiments performed in duplicate). c A2BRKO osteoclasts also degrade more dentin than osteoclasts from WT mice. Data are expressed as mean ± SEM (Student’s t test: *p < 0.05; **p < 0.01)