Table 1.

μCT analysis of subchondral bone. μCT analysis of the hind paws was carried out as described in “Material and methods.” Data are expressed as mean ± SEM of four animals for each group which was then analyzed by two-way ANOVA and Bonferroni post hoc test

	Age (weeks)	GENOT.	BV/TV		BMD		Tb Th		Tb N
Femur	6	WT	32.42 ± 0.91	p value = 0.089	0.3365 ± 0.010	p value = 0.250	0.060 ± 0.001	p value = 0.579	5.41 ± 0.071	p value = 0.002
		A2BRKO	27.88 ± 2.02		0.3054 ± 0.022		0.059 ± 0.004		4.85 ± 0.078
	12	WT	34.40 ± 2.14	p value = 0.598	0.3924 ± 0.010	p value = 0.015	0.065 ± 0.002	p value = 0.377	5.25 ± 0.093	p value = 0.038
		A2BRKO	32.84 ± 0.63		0.357 ± 0.009		0.064 ± 0.001		4.95 ± 0.067
	19	WT	36.07 ± 1.94	p value = 0.743	0.3868 ± 0.019	p value = 0.883	0.069 ± 0.002	p value = 0.657	5.00 ± 0.110	p value = 0.081
		A2BRKO	37.06 ± 2.14		0.3989 ± 0.019		0.073 ± 0.004		4.76 ± 0.040
Tibia	6	WT	35.93 ± 0.69	p value = 0.017	0.3695 ± 0.004	p value = 0.082	0.059 ± 0.006	p value = 0.833	6.01 ± 0.126	p value = 0.002
		A2BRKO	30.23 ± 1.59		0.3268 ± 0.020		0.0590.004		5.15 ± 0.118
	12	WT	38.23 ± 1.71	p value = 0.035	0.3979 ± 0.015	p value = 0.016	0.065 ± 0.002	p value = 0.8407	5.73 ± 0.215	p value = 0.032
		A2BRKO	31.27 ± 1.91		0.3382 ± 0.010		0.065 ± 0.001		4.94 ± 0.189
	19	WT	35.77 ± 0.89	p value = 0.502	0.3900 ± 0.008	p value = 0.577	0.069 ± 0.002	p value = 0.984	5.17 ± 0.218	p value = 0.435
		A2BRKO	34.37 ± 1.74		0.4048 ± 0.024		0.069 ± 0.003		4.94 ± 0.082

Italicized numbers indicate values with a statistically significant p-value