Table 2.

μCT analysis of distal bone. μCT analysis of the hind paws was carried out as described in “Material and methods.” Data are expressed as mean ± SEM of four animals for each group which was then analyzed by two-way ANOVA and Bonferroni post hoc test

	Age (weeks)	GENOT.	BV/TV		BMD		Tb Th		Tb N
Femur	6	WT	10.94 ± 0.7447	p value = 0.037	0.144 ± 0.006	p value = 0.055	0.044 ± 0.001	p value = 0.815	2.493 ± 0.131	p value = 0.036
		A2BRKO	7.97 ± 0.85		0.120 ± 0.008		0.044 ± 0.002		1.806 ± 0.218
	12	WT	17.60 ± 2.67	p value = 0.093	0.020 ± 0.024	p value = 0.085	0.061 ± 0.005	p value = 0.073	2.823 ± 0.223	p value = 0.177
		A2BRKO	12.10 ± 1.41		0.155 ± 0.012		0.050 ± 0.002		2.388 ± 0.188
	19	WT	11.94 ± 1.37	p value = 0.003	0.149 ± 0.007	p value = 0.562	0.057 ± 0.003	p value = 0.276	2.091 ± 0.127	p value = 0.0001
		A2BRKO	5.05 ± 0.25		0.155 ± 0.005		0.063 ± 0.004		0.812 ± 0.065
Tibia	6	WT	7.28 ± 0.26	p value = 0.061	0.114 ± 0.002	p value = 0.088	0.041 ± 0.001	p value = 0.501	1.782 ± 0.063	p value = 0.015
		A2BRKO	5.48 ± 0.74		0.098 ± 0.008		0.043 ± 0.004		1.259 ± 0.142
	12	WT	13.6 ± 1.761	p value = 0.190	0.171 ± 0.017	p value = 0.215	0.055 ± 0.003	p value = 0.116	2.453 ± 0.199	p value = 0.544
		A2BRKO	10.40 ± 1.31		0.143 ± 0.013		0.049 ± 0.001		2.258 ± 0.229
	19	WT	9.73 ± 0.97	p value = 0.0003	0.123 ± 0.017	p value = 0.853	0.054 ± 0.003	p value = 0.157	1.780 ± 0.109	p value = 0.0001
		A2BRKO	2.28 ± 0.31		0.127 ± 0.012		0.061 ± 0.002		0.385 ± 0.072

Italicized numbers indicate values with a statistically significant p-value