Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Sep 15;4:104. doi: 10.3389/fcell.2016.00104

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 Togashi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Checkerboard-like cellular pattern in the mouse auditory epithelium. (A) Molecular interactions between nectins and cadherins (Takai and Nakanishi, 2003). α, α-catenin. (B) Expression pattern of DE-cadherin and DN-cadherin in the Drosophila retina (Hayashi and Carthew, 2004). All cells express DE-cadherin, but only cone cells express DN-cadherin. (C) Homophilic and heterophilic trans-interactions between nectins (Takai and Nakanishi, 2003). N1, nectin-1; N2, nectin-2; N3, nectin-3. Wide arrows, strong interactions; narrow arrows, weak interactions. (D) Cellular rearrangement of the auditory epithelium from embryonic day (E) 14 to E18 (McKenzie et al., 2004; Togashi et al., 2011). (Upper) Localization of ZO-1 at the apical surface of the auditory epithelium. OHCs, outer hair cells; IHC, inner hair cell. (Lower) Schematic illustrations of the cellular rearrangements. Red, differentiated hair cells; green, supporting cells. (E) Expression pattern of nectins and cadherins in the auditory epithelium (Simonneau et al., 2003; Togashi et al., 2011). Nectin-1 is expressed in hair cells, while nectin-3 is expressed in supporting cells. E-cadherin is expressed in the region including the outer hair cells (pink), and N-cadherin is expressed in the medial inner hair cell region (light green). Pillar cells express P-cadherin (light yellow). N1, nectin-1; N3, nectin-3. Red or green lines indicate nectin protein localizations at cell–cell boundaries. (F) Cellular patterning in the auditory epithelia of wild-type and nectin-3 knockout (KO) mice (Togashi et al., 2011). Arrows point to examples of aberrantly attached hair cells.