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. 2016 May 27;594(18):5195–5207. doi: 10.1113/JP271957

Figure 2. NFE2L2 is required for exercise training induced mitochondrial biogenesis .

Figure 2

mtDNA (A), citrate synthase activity (B) and mitochondrial biogenesis‐associated genes mRNA (C) were measured in the skeletal muscle (gastrocnemius) of WT and NFE2L2 KO mice following 6 weeks of treadmill exercise training (trained) or normal sedentary behaviour (untrained). Four‐week treadmill trained NRFE2L2 KO mice had reduced exercise performance (D and E) and energy expenditure (G) compared to trained WT mice. WT and NFE2L2 KO mice had a similar body weight and activity levels (F and H). Results are shown as the mean ± SE (n is shown individually). Significance was determined using one‐way ANOVA with Fisher's least significant difference post hoc analysis. * P < 0.05 ** P < 0.001 vs. untrained or pre‐training of the same genotype. # P < 0.05 vs. WT of the same condition. EE, energy expenditure. [Colour figure can be viewed at wileyonlinelibrary.com]