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. 2016 Aug 4;22(9):203. doi: 10.1007/s00894-016-3065-2

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 11a–f — Destabilization of the homodimer interface by bivalent antagonist 5j. a, b The distance between Tyr37 and Tyr 5.42 in the apo form (a) and in the complex with the ligand (b). c, d The distance between Arg145 and Cys443 in the apo form (d) and in the complex with the ligand (d). e, f The distance between Leu 5.65 and Lys 8.52 in the apo form (e) and in the complex with the ligand (f)