Table 4. Comparison of the clinical and pathologic characteristics as well as disease outcome of the non-endometrioid carcinoma cases with respect to L1CAM expression.
| All | L1CAM− | L1CAM+ | Pa | |
|---|---|---|---|---|
| Number of patients | 104 | 26 (25%) | 78 (75%) | |
| Median age (years) | 69 (range 31–88) | 64 (range 31–83) | 70 (range 49–88) | <0.01 |
| Median follow-upb (months) | 46 (range 0–229) | 52 (range 2–229) | 45 (range 0–129) | 0.15 |
| Treatment | ||||
| Lymphadenectomy | 87 (84%) | 23 (89%) | 64 (82%) | 0.56 |
| Radiotherapy | 51 (49%) | 13 (50%) | 38 (49%) | 0.91 |
| Chemotherapy | 46 (44%) | 10 (39%) | 36 (46%) | 0.50 |
| FIGO stage | ||||
| I | 30 (39%) | 7 (27%) | 23 (30%) | 0.73 |
| II | 15 (14%) | 4 (15%) | 11 (14%) | 1.00 |
| III | 42 (40%) | 14 (54%) | 28 (36%) | 0.11 |
| IV | 17 (16%) | 1 (4%) | 16 (21%) | 0.06 |
| Histology | ||||
| Pure NEEC | 76 (73%) | 17 (65%) | 59 (76%) | 0.32 |
| Mixed EEC/NEEC | 28 (27%) | 9 (35%) | 19 (24%) | |
| Primary NEEC component | ||||
| Serous | 61 (59%) | 14 (54%) | 47 (60%) | 0.57 |
| Clear cell | 22 (21%) | 4 (15%) | 18 (23%) | 0.58 |
| Carcinosarcoma | 14 (14%) | 5 (19%) | 9 (12%) | 0.33 |
| Undifferentiated | 7 (7%) | 3 (12%) | 4 (5%) | 0.36 |
| Myometrial invasion | ||||
| <1/2 | 39 (38%) | 13 (50%) | 26 (33%) | 0.13 |
| ⩾1/2 | 65 (63%) | 13 (50%) | 52 (67%) | |
| LVSI | ||||
| No | 43 (54%) | 18 (78%) | 25 (44%) | <0.01 |
| Yes | 37 (46%) | 5 (22%) | 32 (56%) | |
| Unknown | 24 | 3 | 21 | |
| Outcome | ||||
| Residual disease | 21 (20%) | 2 (8%) | 19 (24%) | 0.09 |
| Recurrence | 32 (39%) | 6 (25%) | 26 (44%) | 0.14 |
| Locoregional | 13 (16%) | 4 (17%) | 9 (15%) | 1.00 |
| Distant | 25 (30%) | 4 (17%) | 21 (36%) | 0.12 |
| Deceased | 45 (43%) | 10 (39%) | 35 (45%) | 0.57 |
| Endometrial cancer | 36 (35%) | 6 (23%) | 30 (39%) | 0.23 |
Abbreviations: EEC=endometrioid endometrial carcinoma; FIGO=International Federation of Gynaecology and Obstetrics; L1CAM=L1 cell adhesion molecule; LVSI=lymphovascular space invasion; NEEC=non-endometrioid carcinoma.
a
P-value for the Mann–Whitney U-test for continuous variables, and χ2 test for categorical variables. Bold values indicate that the differences were considered to be significant.
b
Median follow-up including deceased patients.