Table 3. OR for UCC and genome-wide measures of DNA methylation by CpG subgroup and disease subtype.

		All cases			Invasive cases			Superficial cases
	N CpGs	ORa	95% CI	P	OR	95% CI	P	OR	95% CI	P
CpG region
Islands	71 728	0.97	0.81–1.15	0.72	1.04	0.79–1.36	0.77	0.89	0.69–1.15	0.39
Shores	51 833	0.87	0.73–1.05	0.15	1.02	0.77–1.36	0.86	0.73	0.56–0.95	0.02
Shelves	14 261	0.94	0.79–1.12	0.50	0.79	0.59–1.06	0.11	1.07	0.84–1.37	0.58
None	58 438	0.99	0.83–1.18	0.90	0.83	0.63–1.10	0.20	1.13	0.89–1.43	0.33
Regulatory regions
Promoters	94 695	0.93	0.77–1.11	0.41	1.04	0.78–1.38	0.79	0.82	0.63–1.07	0.13
Other regulatory	46 154	0.92	0.78–1.09	0.32	1.02	0.78–1.33	0.88	0.80	0.63–1.02	0.07
Not regulatory	55 411	0.92	0.77–1.11	0.39	0.76	0.56–1.04	0.08	1.05	0.81–1.35	0.71
Within promoters
HCP	51 208	1.01	0.84–1.22	0.90	1.03	0.76–1.39	0.85	0.99	0.76–1.28	0.93
ICP	21 983	0.89	0.74–1.08	0.24	1.06	0.79–1.41	0.71	0.75	0.57–0.98	0.03
LCP	21 504	0.97	0.82–1.15	0.73	0.84	0.64–1.11	0.22	1.06	0.84–1.35	0.60

Abbreviations: CI=confidence interval; HCP=high-density CpG promoter; ICP=intermediate-density CpG promoter; LCP=low-density CpG promoter; OR=odds ratio; UCC=urothelial cell carcinoma.

^aORs per s.d. in median M-value were calculated using conditional logistic regression models, with matching on age, sex, ethnicity, type of sample, plate, and chip, and adjusting for smoking status, alcohol intake, body mass index (BMI), folate intake, vitamin B12 intake, and socioeconomic status.