Table 4. Genome-wide measure of DNA methylation and UCC risk by disease subtype: effect modification by smoking, time since blood collection, and sex.

	All cases			Invasive cases			Superficial cases
	ORa	95% CI	P	ORb	95% CI	P	ORb	95% CI	P
Smoking status at blood collection
Never	0.94	0.71–1.25	0.65	0.90	0.59–1.37	0.63	0.99	0.66–1.47	0.95
Current	0.68	0.46–0.99	0.05	1.06	0.61–1.86	0.83	0.47	0.27–0.83	0.01
Former	0.91	0.72–1.17	0.47	1.21	0.85–1.73	0.30	0.65	0.44–0.94	0.02
Heterogeneity test	P=0.30			P=0.51			P=0.03
Time since blood collection
<5 Years	0.77	0.55–1.09	0.14	1.00	0.64–1.60	0.97	0.66	0.44–0.98	0.04
5–10 Years	1.10	0.78–1.57	0.58	0.93	0.59–1.47	0.62	1.04	0.65–1.65	0.89
>10 Years	0.72	0.43–1.20	0.21	1.72	0.87–3.40	0.12	0.51	0.28–0.94	0.03
Heterogeneity test	P=0.34			P=0.22			P=0.07
Sex
Male	0.89	0.72–1.11	0.31	1.09	0.80–1.50	0.56	0.82	0.62–1.08	0.16
Female	0.66	0.36–1.22	0.18	1.43	0.66–3.09	0.36	0.59	0.24–0.96	0.05
Heterogeneity test	P=0.50			P=0.20			P=0.19

Abbreviations: CI=confidence interval; OR=odds ratio; UCC=urothelial cell carcinoma.

^aORs per s.d. in median M-value were calculated using conditional logistic regression models, with matching on age, sex, ethnicity, type of sample, plate, and chip, and adjusting for smoking status, alcohol intake, time since blood draw, body mass index (BMI), folate intake, vitamin B12 intake, and socioeconomic status.

^bAdjusting for the matching variables, and smoking status and time since blood draw only, because of relatively small numbers of observed cases.